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ea0056oc10.2 | Cardiovascular aspects of endocrine diseases | ECE2018

Canagliflozin attenuates the progression of atherosclerosis via reducing hyperlipidaemia and inflammation process in ApoE KO Mice

Nasiri-Ansari Narjes , Dimitriadis Georgios K. , Agorogiannis George , Perrea Despina , Daikos George , Papavassiliou Athanasios G. , Kaltsas Gregory , Randeva Harpal S. , Kassi Eva

Introduction: Treatment with sodium glucose co-transporter2(SGLT2) inhibitors was found to reduce the incidence of cardiovascular events in diabetic patients.Herein, we investigated the effects of long-term treatment with canagliflozin on atherosclerosis development in the aorta of Apolipoprotein E knockout (Apo-E(−/−)) mice as well as on biochemical and immunohistochemical markers related to atherosclerosis.Methods: At 4 weeks of ...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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